Although most of our interests lie in the area of synthetic methodology, we have also decided to tackle the miscellaneous natural product because of its structural novelty or interesting biological activity. Sometimes these projects come full circle and suggest new synthetic methods for future exploration. A couple of such targets are shown below.
Lead References
1. Total Synthesis of (+)-Curacin A, a Marine Cytotoxic Agent. Hoemann, M. Z.; Agrios, K. A.; Aubé, J. Tetrahedron 1997, 53, 11087-11098.
2. Cyclizations of Substituted Benzylidene-3-alkenylamines: Synthesis of the Tricyclic Core of the Martinellines. Frank, K. E.; Aubé, J. J. Org. Chem. 2000, 65, 655-666.
For More Information Contact:
Department of Medicinal Chemistry
4070 Malott Hall
Tel: 785-864-4495
FAX: 785-864-5326
Internet: jaube@ku.edu
