Publications:
1. Interaction of melittin with endotoxic lipid A. SA David, VI Mathan & P Balaram. Biochim. Biophys. Acta (1992) 1123: 269-274.
2. Analysis of the binding of polymyxin B to endotoxic lipid A and core glycolipid using a fluorescent displacement probe. SA David, KA Balasubramanian, VI Mathan & P Balaram. Biochim. Biophys. Acta. (1992) 1165: 147-152.
3. Interaction of basic amphiphilic polypeptide antimicrobials, Gramicidin S, Tyrocidin, and Efrapeptin, with endotoxic lipid A. SA David, P Balaram & VI Mathan. Med. Microbiol. Lett (1993) 2: 42-47.
4. Enzyme-linked immunosorbent assay for quantification of anti-lipid A antibody: Enhancement of sensitivity by antigen immobilization at low pH. SA David & VI Mathan. J. Immunol. Methods (1993) 163: 85-89.
5. Enteric vascular endothelial response to bacterial endotoxin. R Koshi, VI Mathan, SA David & MM Mathan. Int. J. Exp. Path. (1993) 74: 593-601.
6. Interaction of cationic amphiphilic drugs with lipid A: Implications for development of endotoxin antagonists. SA David, B Bechtel, C Annaiah, VI Mathan & P Balaram. Biochim. Biophys. Acta. (1994) 1212: 167-175.
7. An update on plague. SA David & VI Mathan. Current Science (1994) 67: 710-713.
8. Characterization of the interaction of lipid A and lipopolysaccharide with human serum albumin: Implications for an endotoxin carrier function for albumin. SA David, P Balaram & VI Mathan. J. Endotoxin Res. (1995) 2: 99-106.
9. Interactions of linear dicationic molecules with lipid A: Structural features that correspond to optimal binding affinity. SA David, VI Mathan & P Balaram. J. Endotoxin Res. (1995) 2: 325-336.
10. Characterization of the interactions of a polycationic, amphiphilic, terminally-branched oligopeptide with lipid A and lipopolysaccharide from the deep rough mutant of Salmonella minnesota. SA David, SK Awasthi, A Wiese, AJ Ulmer, B Lindner, K Brandenburg, U Seydel, ET Rietschel, A Sonesson & P Balaram. J. Endotoxin Res. (1996) 3: 369-379.
11. Polymyxin B nonapeptide: Conformations in water and in the lipopolysaccharide-bound state determined by 2D-NMR and molecular dynamics. S Bhattacharjya, SA David, VI Mathan & P Balaram. Biopolymers. (1997) 41: 251-265.
12. Lipopolyamines: Novel antiendotoxin compounds that reduce mortality in experimental sepsis. SA David, R Silverstein, C Amura, T Kielian & DC Morrison. Antimicrob. Agents Chemother. (1999) 43: 912-919.
13. Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide. IS Blagbrough, AJ Geall & SA David. Bioorg. Med. Chem. Lett. (2000) 10: 1959-1962.
14. The role of polar and facial amphipathic character in determining lipopolysaccharide-binding properties in synthetic cationic peptides. SA David, SK Awasthi & P Balaram. J. Endotoxin Res. (2000) 6: 249-256.
15. Selective transmission of R5-tropic HIV-1 from dendritic cells to resting CD4+ T cells. SA David, M Smith, G Lopez, S Mukherjee, S Buch & O Narayan. AIDS Res. Hum. Retrovir. (2001) 17: 59-68.
16. Towards a rational development of anti-endotoxin agents: novel approaches to sequestration of bacterial endotoxins with small molecules. (Invited review) SA David. J. Molec. Recognition. (2001) 14: 370-387.
17. Sequestration of bacterial lipopolysaccharide by bis(args) gemini compounds. SA David & L Pérez M.-R. Infante. Bioorg. Med. Chem. Lett. (2002) 12: 357-360.
18. Anti-Endotoxin Agents. 1. Development of a Fluorescent Probe Displacement Method Optimized for the Rapid Identification of Lipopolysaccharide-Binding Agents. SJ Wood, KA Miller & SA David. Comb. Chem. High Throughput Screen. (2004) 7: 239-249.
19. Anti-Endotoxin Agents. 2. Pilot High-Throughput Screening for Novel Lipopolysaccharide-Recognizing Motifs in Small Molecules. SJ Wood, KA Miller & SA David. Comb. Chem. High Throughput Screen. (2004) 7: 733-743.
20. Lipopolysaccharide Sequestrants: Structural Correlates of Activity and Toxicity in Novel Acylhomospermines. KA Miller, EVK Suresh Kumar, SJ Wood, JR Cromer, A Datta, & SA David. J. Med. Chem. (2005) 48: 2589-2599.
21. Functionalized Dendrimers as Endotoxin Sponges. JR Cromer, SJ Wood, KA Miller, T Nguyen, & SA David. Bioorg. Med. Chem. Lett. (2005). 15: 1295-1298.
22. Lysine-Spermine Conjugates: Hydrophobic Polyamine Amides as Potent Lipopolysaccharide Sequestrants. MR Burns, SJ Wood, KA Miller, T Nguyen, JR Cromer, & SA David. Bioorg. Med. Chem. (2005) 13: 2523-2536.
23. Molecular Modeling Analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharides. JX Guo, SJ Wood, SA David & GH Lushington. Bioorg. Med. Chem. Lett. (2006) 16: 714-717.
24. Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds. K Khownium, SJ Wood, KA Miller, R Balakrishna, TB Nguyen, MR Kimbrell, GI Georg & SA David. Bioorg. Med. Chem. Lett. (2006) 16: 1305-1308.
25. MR Burns, SA Jenkins, SJ Wood, K Miller & SA David. Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library. J. Comb. Chem. (2006) 8: 32-43.
26. Anti-endotoxin agents. 3. Rapid identification of high-affinity lipopolysaccharide-binding compounds in a substituted polyamine library. SJ Wood, KA Miller, GH Lushington, MR Burns & SA David. Comb. Chem. High Throughput Screen. (2006) 9:27-36.
27. Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines. R Balakrishna, SJ Wood, TB Nguyen, KA Miller, EVK Suresh Kumar, A Datta & SA David. Antimicrob. Agents Chemother. (2006) 50:852-861.
28. Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs. MR Burns, SA Jenkins, NM Vermeulen, R Balakrishna, TB Nguyen, MR Kimbrell & SA David. Bioorg Med Chem Lett. (2006) 16:6209-6212.
29. Further Exploration of Antimicrobial Ketodihydronicotinic Acid Derivatives by Multiple Parallel Syntheses. JB Laursen, J Nielsen, T Haack, S Pusuluri, S David, R Balakrishna, Y Zeng, Z Ma, TB Doyle & LA Mitscher. Comb. Chem. High Throughput Screen. (2006) 9:663-671.
30. Polycationic Sulfonamides for the Sequestration of Endotoxin. MR Burns, S Jenkins, MR Kimbrell, R Balakrishna, TB Nguyen, BG Abbo & SA David. J. Med. Chem. (2007) 50: 877-888.
31. Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide. TB Nguyen, AK Adisechan, EV Suresh Kumar, R MR Balakrishna, Kimbrell, KA Miller, A Datta & SA David. Bioorg. Med. Chem. (2007) 15: 5694-709.
32. Bound to Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant. D Sil, A Shrestha, MR Kimbrell, TB Nguyen, AK Adisechan, R Balakrishna, BG Abbo, S Malladi, KA Miller, S Short, JR Cromer, S Arora, A Datta & SA David. Antimicrob. Agents Chemother. (2007) 51: 2811-2819.
33. High-resolution solution structure of a designed peptide bound to lipopolysaccharide: transferred nuclear Overhauser effects, micelle selectivity, and anti-endotoxic activity. S Bhattacharjya, PN Domadia, A Bhunia, S Malladi & David SA. Biochemistry (2007) 46:5864-74.
34. Pharmacokinetics of DS-96, an Alkylpolyamine Lipopolysaccharide Sequestrant, in Rodents. A Shrestha, R Li, D Sil, NN Pardeshi, N Schwarting, KS Schorno, RA Rajewski, A Datta & SA David. J Pharm Sci. (2008) 97: 5376-5385.
35. Interactions of a designed peptide with lipopolysaccharide: Bound conformation and anti-endotoxic activity. A Bhunia, PN Domadia, GL Chua, H Warshakoon, JR Cromer, SA David & S Bhattacharjya. Biochem. Biophys. Res. Commun. (2008) 369: 863-7.
36. Comparison of the Immunostimulatory and Proinflammatory Activities of Candidate Gram-Positive Endotoxins, Lipoteichoic Acid, Peptidoglycan, and Lipopeptides in Murine and Human Cells. MR Kimbrell, H Warshakoon, JR Cromer, S Malladi, R Balakrishna, TA Scholdberg & SA David. Immunol.Lett. (2008)118:132-41.
37. Controlling Plasma Protein Binding: Structural Correlates of Interactions of Hydrophobic Polyamine Endotoxin Sequestrants with Human Serum Albumin. TB Nguyen, EVK Suresh Kumar, D Sil, SJ Wood, KA Miller, H Warshakoon, A Datta & SA David. Molec. Pharmaceutics. (2008) 5:1131-1137.
38. Structure-Activity Relationships of Lipopolysaccharide Sequestration in Guanylhydrazone-bearing Lipopolyamines. W Wu, D Sil, ML Szostak, S Malladi, HJ Warshakoon, MR Kimbrell, JR Cromer & SA David. Bioorg. Med. Chem. (2009) 17:709-715.
39. Structure-Activity Relationships of Antimicrobial and Lipoteichoic Acid Sequestering Properties in Polyamine Sulfonamides. HJ Warshakoon, MR Burns & SA David. Antimicrob. Agents Chemother. (2009) 53: 57-62.
40. Invited Review: Potential Adjuvantic Properties of Innate immune Stimuli. HJ Warshakoon, JD Hood, MR Kimbrell, S Malladi, W Wu, N Shukla, G Agnihotri, D Sil & SA David. Human Vaccines. In Press.
41. Regioisomerism-dependent TLR7 Agonism and Antagonism in an Imidazoquinoline. NM Shukla, MR Kimbrell, SS Malladi & SA David. Bioorg. Med. Chem.Lett. In Press.
Book Chapters:
42. The interactions of human serum albumin with lipid A and LPS. SA David. Endotoxin in Health and Disease. (DC Morrison, H. Brade, S. Opal, S. Vogel, Eds.) Marcel Dekker. Chapter 24; Pages 413-422. 1997.
43. Macaque models of neuropathogenesis of HIV infection. S Buch, SA David, PD Cheney, R Raghavan and O Narayan. New Concepts on the Immunopathogenesis of CNS Infections. (DK Peterson & J Remington, Eds.) Blackwell Science. 2000.
For More Information, Please Contact:
Sunil A. David, MD, PhD
Department of Medicinal Chemistry, University of Kansas
Multidisciplinary Research Building, Room 320D
2030 Becker Drive
Lawrence KS 66047
Tel: 785-864-1610
Fax: 785-864-1961
E-mail:
sdavid@ku.edu
http://www.medchem.ku.edu/faculty_david.shtml
