Department of Medicinal Chemistry
Research areas include asymmetric total synthesis of natural and non-natural compounds of biomedical significance (anti-infectives and anti-cancer), and, development of new organic synthetic methodologies. An important tool in our synthetic endeavors continues to be the utilization of easily available enantiopure amino acids as chiral building blocks towards stereoselective synthesis of desired target compounds (chiral pool approach).The current synthetic efforts are directed towards biological targets such as:
- HIV Reverse Transcriptase (AIDS)
- Chitin Synthase (anti-fungal)
- Endotoxins / Lipopolysachharides (septic shock)
- Proteasome (anti-cancer)
Some of the natural product targets in our total synthesis studies include:
- The potent antifungal complex nucleoside antibiotics, Polyoxins, Nikkomycins, Ezomycins, Amipurimycin etc.
- Proteasome inhibitor novel cytotoxic marine natural product Salinosporamide A.
In a recently initiated combinatorial chemistry (CombiChem) research program, synthesis of libraries of biomimetics (novel nucleosides, azacarbohydrates etc) and their subsequent high throughput screening (HTS) against various biological targets are being investigated.