Publications
Research Group
Research Projects
• Ph.D. (1989): North-Eastern Hill University, Shillong, India
• Alexander von Humboldt Postdoctoral Fellow (1991-92): University of Konstanz, Germany
• Postdoctoral Fellow (1993-94): University of Kansas, Lawrence, USA
Research Interests
Research areas include asymmetric total synthesis of natural and non-natural compounds of biomedical significance
(anti-infectives and anti-cancer), and, development of new organic synthetic methodologies. An important tool in our
synthetic endeavors continues to be the utilization of easily available enantiopure amino acids as chiral building
blocks towards stereoselective synthesis of desired target compounds (chiral pool approach).
The current synthetic efforts are directed towards biological targets such as:
• HIV Reverse Transcriptase (AIDS)
• Chitin Synthase (anti-fungal)
• Endotoxins / Lipopolysachharides (septic shock)
• Proteasome (anti-cancer)
Some of the natural product targets in our total synthesis studies include:
• The potent antifungal complex nucleoside antibiotics, Polyoxins, Nikkomycins, Ezomycins, Amipurimycin etc.
• Proteasome inhibitor novel cytotoxic marine natural product Salinosporamide A.
In a recently initiated combinatorial chemistry (CombiChem) research program, synthesis of libraries of biomimetics
(novel nucleosides, azacarbohydrates etc) and their subsequent high throughput screening (HTS) against various biological
targets are being investigated.
For More Information, Please Contact:
Dr. Apurba Dutta
Department of Medicinal Chemistry - KU
1251 Wescoe Hall Dr.
5006 Malott Hall
Lawrence, KS 66045-7582 USA
Phone: (785) 864-4117
Fax: (785) 864-5329
Email:
adutta@ku.edu
